Advise the patient to read the FDA-approved patient labeling (Patient Information). Tell your doctor if you’re pregnant or plan to become pregnant. This is not a complete list of side effects. Dispense in a tight, light-resistant container. This leaflet summarizes the most important information about Losartan potassium tablets. Alcohol can also increase the blood pressure-lowering effect of losartan. You can also check your blood pressure at home. This drug may cause low blood pressure, which can make you feel faint or dizzy. Keep Losartan potassium tablets and all medicines out of the reach of children. Losartan potassium tablets can help your blood vessels relax so your blood pressure is lower. In general, avoid combined use of RAS inhibitors. Neither Losartan nor its active metabolite can be removed by hemodialysis [see Warnings and Precautions (5.3) and Use in Specific Populations (8.7)]. Fetal testing may be appropriate, based on the week of pregnancy. After one month, investigators were instructed to titrate study drug to 100 mg once daily if the trough blood pressure goal (140/90 mmHg) was not achieved. Also tell them about any vitamins, herbs, and supplements you use. For the primary endpoint and ESRD, the effects of Losartan potassium in patient subgroups defined by age, gender and race are shown in Table 5 below. Frequently asked questions about losartan (Cozaar) Is losartan (Cozaar) bad for the kidneys? If symptomatic hypotension should occur, supportive treatment should be instituted. Dosages range between 25 and 100 mg per day. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus [see Warnings and Precautions (5.1)]. Analysis of age, gender, and race subgroups of patients showed that men and women, and patients over and under 65, had generally similar responses. Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in Black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart failure, or diabetic kidney disease). See "What is the most important information I should know about Losartan potassium tablets?". General information about Losartan potassium tablets. Be sure to avoid doing this when the weather is very hot or very cold. Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy … A class of drugs is a group of medications that work in a similar way. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Below is a list of medications that can interact with losartan. The Risk Reduction is adjusted for baseline Framingham risk score and level of electrocardiographic left ventricular hypertrophy. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. There are no specific recommendations for senior dosage. The usual starting dose is 50 mg once daily. Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. There is also an AT2 receptor found in many tissues but it is not known to be associated with cardiovascular homeostasis. The principal pharmacokinetic parameters in adults and children are shown in the table below. Share on Pinterest The dosage for losartan potassium can vary, and people should take it as prescribed. They will slowly taper your dosage so that you can stop using the drug safely. To do this, you may need to buy a home blood pressure monitor. Hypersensitivity: Angioedema, including swelling of the larynx and glottis, causing airway obstruction and/or swelling of the face, lips, pharynx, and/or tongue has been reported rarely in patients treated with Losartan; some of these patients previously experienced angioedema with other drugs including ACE inhibitors. It is not known whether Losartan is excreted in human milk, but significant levels of Losartan and its active metabolite were shown to be present in rat milk. Figure 4: Kaplan-Meier curve for the primary composite endpoint of doubling of serum creatinine, end stage renal disease (need for dialysis or transplantation) or death. That inhibit the renin angiotensin system and by diuretics bottle well before each.! Examinations to assess the intra-amniotic environment 911 or go to the elimination of Losartan was studied in one trial 177. 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